Summer Undergraduate Research Mentored Experience

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Dr. Devesh Misra

Department of Metallurgical & Materials Engineering

Synthesis of nanomaterials for biomedical applications

Preferred major field of study or minimum required skills

We will train the students in different characterization methods.

Scholarly significance/intellectual merit

The capability of synthesizing and processing biomaterial surfaces with tailored surface morphology and consequently control assembly of proteins, provides the possibility of eliciting specific, timely, and desirable response from the surrounding cells and tissues necessary for implant efficiency. Other broader impacts are: (a) Protein adsorption is relevant to fields such as tissue regeneration, prosthetics, and drug delivery because in each of these cases protein adsorption is the primary event. The study of adsorption behavior of protein on stainless steels is practically relevant to stent applications, where stainless steel and NiTi alloys are used. (b) The insights acquired from the proposed research using stainless steel, is directly applicable to other metals (e.g. titanium alloys), ceramics, and nanoscale structure of polymers because of similarity in the relationship between surface morphology, protein adsorption and cellular activity. (c) Understanding of protein adsorption at biointerfaces impacts interfacial processes in neurobiology and bio-nanotechnology. In neurobiolog

Research question(s)

The research addresses following issues:

  1. what is the origin of differences in protein adsorption at biointerfaces and the mechanisms involved,
  2. how do the differences in protein adsorption at biointerfaces influence osteoblasts functions, and
  3. what are the mechanisms that govern protein-cell interactions

Methods/techniques/instruments to be learned/utilized

Task I. Study the relationship between self-assembled structure of pre-adsorbed protein and physico-chemical properties of surface

Task II. Study the dependence of cellular and molecular activity on self-assembled structure of pre-adsorbed proteins

Task III. Study the organization of key proteins involved in cellular activity and biological functions